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Mechanism of Action: Tirzepatide vs Exendin-4-Based GLP-1 Agonists Understanding the mechanistic differences between tirzepatide and exendin-4-based therapies is essential for appreciating their distinct clinical profiles
Tirzepatide (Mounjaro/Zepbound), also made by Eli Lilly, is a dual GLP-1/GIP agonist
They: Increase insulin secretion in response to meals Suppress glucagon, a hormone that raises blood sugar Slow gastric emptying, which helps you feel full longer Reduce appetite, often leading to weight loss This combination makes them effective for both diabetes management and weight reduction Nausea is a common side effect when starting GLP-1 medications because they slow digestion and affect appetite signals in the brain
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